姓名：李紫文

职称：副教授

所属系所：生物农业研究院

办公地点：北京科技大学西三旗校区8号楼207室（北京市海淀区建材城东路10号京城尚德智造产业园）

办公电话：010-82917178

电子邮件：liziwen@ustb.edu.cn

本科课程：参与《生物信息学与应用》

研究生课程：参与《作物生物遗传育种》

科研方向：基因组与生物信息学

简 历：

2018.11至今，北京科技大学，讲师/副教授

2017.11至2018.10，北京科技大学，助理研究员

2013.07至2017.10，中国科学院植物研究所，博士后

2008.07至2013.06，西南大学，博士

2004.09至2008.06，西南大学，学士

科研业绩:近五年，主要从事作物生物信息学及其应用研究，揭示玉米雄性不育和优良性状形成的遗传基础和基因分子功能。主持和参与国家重点研发计划和北京市科技计划项目等6项，发表SCI论文20余篇，参与撰写出版英文专著2部，参与申请国家发明专利4项，获得科研奖励4项。

获得奖励/发明专利：

1、 2022年，第七届中国科协优秀科技论文遴选计划优秀论文，中国科学技术协会

2、 2021年，生产力促进奖（创新发展）二等奖，中国生产力促进中心协会

3、 2020年，第五届中国科协优秀科技论文遴选计划优秀论文，中国科学技术协会

4、 2020年，北京科技大学2019年度十大科学进展，北京科技大学

代表性论文论著：

（#共同第一作者，*通讯作者）

  1、 Li Z#, Liu S#, Zhu T, Wang J, Sun M, An X, Wei X, Liu C, Chu J, Wan X*. Jasmonic acid-mediated stress responses share the molecular mechanism underlying male sterility induced by deficiency of ZmMs33 in maize. Crop J. 2023，11(4):1115-1127.

  2、 Li Z#, Zhu T#, Liu S#, Zhao L, An X, Long Y, Wei X, Zhang J, Dong Z, Wan X*. ZmMs33 promotes anther elongation via modulating cell elongation regulators, metabolic homeostasis, and cell wall remodeling in maize. Crop J, 2023, 11(2):361-373.

  3、 Li Z#, Liu S#, Zhu T#, An X, Wei X, Zhang J, Wu S, Dong Z, Long Y*, Wan X*. The loss-function of the male sterile gene ZmMs33/ZmGPAT6 results in severely oxidative stress and metabolic disorder in maize anthers. Cells, 2022, 11(15):2318.

  4、 Jiang Y#, Li Z#, Liu X, Zhu T, Xie K, Hou Q, Yan T, Niu C, Zhang S, Yang M, Xie R, Wang J, Li J, An X*, Wan X*. ZmFAR1 and ZmABCG26 regulated by microRNA are essential for lipid metabolism in maize anther. Int J Mol Sci, 2021, 22(15):7916.

  5、  Li Z#, Zhu T#, Liu S#, Jiang Y, Liu H, Zhang Y, Xie K, Li J, An X*, Wan X*. Genome-wide analyses on transcription factors and their potential microRNA regulators involved in maize male fertility. Crop J, 2021, 9:1248-1263.

  6、 Jiang Y#, An X#, Li Z#, Yan T, Zhu T, Xie K, Liu S, Hou Q, Zhao L, Wu S, Liu X, Zhang S, He W, Li F, Li J, Wan X*. CRISPR/Cas9-based discovery of maize transcription factors regulating male sterility and their functional conservation in plants. Plant Biotechnol J, 2021, 19(9):1769-1784.

  7、 Zhu T#, Li Z#, An X#, Long Y#, Xue X, Xie K, Ma B, Zhang D, Guan Y, Niu C, Dong Z, Hou Q, Zhao L, Wu S, Li J, Jin W, Wan X*. Normal structure and function of endothecium chloroplasts maintained by ZmMs33-mediated lipid biosynthesis in tapetal cells are critical for anther development in maize. Mol Plant, 2020, 13(11):1624-1643.

8、 Zhang Y#, Li Z#, Ma B, Hou Q, Wan X*. Phylogeny and functions of LOB domain proteins in plants. Int J Mol Sci. 2020, 21(7):2278.

  9、 Li Z#, An X#, Zhu T, Yan T, Wu S, Tian Y, Li J, Wan X*. Discovering and constructing ceRNA-miRNA-target gene regulatory networks during anther development in Maize. Int J Mol Sci. 2019, 20(14):3480.

  10、 Li Z, Wan X*. Long-term evolutionary DNA methylation dynamic of protein-coding genes and its underlying mechanism. Gene, 2018, 677:96-104.

  11、 Xie K#, Wu S#, Li Z#, Zhou Y, Zhang D, Dong Z, An X, Zhu T, Zhang S, Liu S, Li J, Wan X*. Map-based cloning and characterization of Zea mays male sterility33 (ZmMs33) gene, encoding a glycerol-3-phosphate acyltransferase. Theor Appl Genet, 2018, 131(6):1363-1378.

  12、 Li ZW#, Hou XH#, Chen JF, Xu YC, Wu Q, Gonzále J, Guo YL*. Transposable elements contribute to the adaptation of Arabidopsis thaliana. Genome Biol Evol, 2018, 10(8):2140-2150.

  13、 Li ZW, Chen X, Wu Q, Hagmann J, Han TS, Zou YP, Ge S, Guo YL*. On the origin of de novo genes in Arabidopsis thaliana populations. Genome Biol Evol, 2016, 8(7):2190-2202.

  14、 Li ZW, Shen YH, Xiang ZH, Zhang Z*. Pathogen-origin horizontally transferred genes contribute to the evolution of Lepidopteran insects. BMC Evol Biol, 2011, 11:356.

  15、 Li ZW, Li X, Yu QY, Xiang ZH, Kishino H, Zhang Z*. The small heat shock protein (sHSP) genes in the silkworm, Bombyx mori, and comparative analysis with other insect sHSP genes. BMC Evol Biol, 2009, 9:215.

专著和教材:

  1、 Wan X*, Li Z*. Plant comparative transcriptomics reveals functional mechanisms and gene regulatory networks involved in anther development and male sterility. In: Transcriptome Analysis. Intechopen. 2019, ISBN 978-1-78984-328-6.

  2、Wan X*, Li Z*. Computational identification of ceRNA and reconstruction of ceRNA regulatory network based on RNA-seq and small RNA-seq data in plants. In: Modeling transcriptional regulation: methods and protocols. Methods in Molecular Biology. Springer. 2021. ISBN-13: 978-1071615331, ISBN-10: 1071615335.

研究生培养情况：协助培养毕业博士1人、毕业硕士3人、在读硕士研究生2人；培养在读硕士研究生2人。